31 C. Ryan* G. Cagney* N. Krogan* P. Cunningham D. Greene 9998 Network Biology: Methods and Protocols bioinformatics,emaps,imputation,krogan <p>Epistatic miniarray profiles (E-MAPs) are a high-throughput approach capable of quantifying aggravating or alleviating genetic interactions between gene pairs. The datasets resulting from E-MAP experiments typically take the form of a symmetric pairwise matrix of interaction scores. These datasets have a significant number of missing values - up to 35% - that can reduce the effectiveness of some data analysis techniques and prevent the use of others.</p>